As part of the LCI-SAR-STS-PEM-001 study, Levine will evaluate the correlation between immunotherapy markers (PD-L1 expression levels) and the clinical effectiveness of pembrolizumab, investigate other biomarkers that may correlate with tumor responses, and evaluate differences in tumor tissue characteristics in biopsies taken during or post-treatment with pembrolizumab versus baseline. (Study fully enrolled). This study was chosen by the Scientific Program Committee of the American Society of Clinical Oncology (ASCO) for a prestigious poster discussion at the May 2020 ASCO Annual Meeting due to the significance of the study’s results.Read More
Dr. Edward Kim, Chair of Solid Tumor Oncology and Investigative Therapeutics, Atrium Health’s Levine Cancer Institute, discusses results of the Institute’s first pilot study in soft tissue sarcomas; its poster discussion honor at ASCO 2020, and its ability to conduct significant investigator-initiated research through its partnership with the Paula Takacs Foundation for Sarcoma Research.Watch Video
This prospective, observational study of patients with intermediate- and high-grade bone and soft tissue sarcomas will evaluate the use of a sarcoma-specific liquid biopsy circulating tumor DNA technique capable of identifying molecular patterns in sarcoma patients’ blood samples and correlating them with treatment response and disease progression. Blood specimens will be collected at various time points during a patient’s disease from diagnosis to up to two years post-treatment. Plasma samples will be sequenced to identify structural variants and targeted translocations that are specific to sarcoma. The molecular patterns identified by liquid biopsy will be compared to standard surveillance methods utilized to detect treatment response and distant metastasis. The results of this study will provide valuable information that will allow for more effective patient management and a greater understanding of the underlying mechanisms driving sarcomas.
Researchers are analyzing certain tissue samples in sarcoma patients across the Levine Cancer Institute network to identify unique biomarkers. These studies hope to uncover actionable mutations that may be used to structure future studies/clinical trials.
Completed 10 years of clinical data and 600 biomarkers tested on 41 specimens. Genomic testing (600 genes), IHC, FISH/CISH, and expression analysis were performed on 41 tissue samples and correlated with 10 years of clinical outcomes. One of the largest retrospective studies in liposarcoma to date.Read the abstract
Kneisl, J. S., Ferguson, C., Robinson, M., Crimaldi, A., Ahrens, W., Symanowski, J., . . . Kim, E. S. (2017). The effect of radiation therapy in the treatment of adult soft tissue sarcomas of the extremities: A long-term community-based cancer center experience. Cancer Medicine,6(3), 516-525. doi:10.1002/cam4.972Read More
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