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The Paula Takacs Foundation for Sarcoma Research proudly provides funding for the SARC038 clinical trial site at Levine Cancer Institute and Levine Cancer Institute

Thanks to the generosity of our corporate and individual donors, our foundation is helping pediatric and adult sarcoma patients in the Carolinas gain access to cutting-edge treatments by providing SARC038 trial site funding at Levine Cancer Institute and Levine Children’s Hospital. In funding these sites, we are bringing novel therapies to patients where they live so that families are relieved of the stress of long-distance travel to find new treatments.

This clinical trial will open shortly and can enroll patients as young as 5 years old. The clinical trial drugs are a targeted therapy and an immunotherapy. Every effort will be made to ensure that 50% of patients will be ≤ 21 years of age.

 

SARC038: A Phase 2 Study of Regorafenib and Nivolumab in Osteosarcoma

TYPE OF SARCOMA: Osteosarcoma
DRUG: Regorafenib, Nivolumab
ACCRUAL STATUS: Recruiting

OVERALL STUDY PRINCIPAL INVESTIGATORS:
Fariba Navid, MD
Children’s Hospital of Los Angeles
Lara Davis, MD
Oregon Health and Sciences University

CLINICALTRIALS.GOV IDENTIFIER: NCT04803877

FOR STUDY DETAILS AND ELIGIBILITY CRITERIA: CLINICALTRIALS.GOV

 

About SARC038

Dr. Fariba Navid, Principal Investigator of SARC038, speaks about the clinical trial.

Osteosarcoma of the bone is a disease in which malignant (cancer) cells form in bone.

Osteosarcoma is the most common type of bone cancer. Osteosarcoma usually starts in osteoblasts, which are a type of bone cell that becomes new bone. Osteosarcoma is most common in adolescents. It commonly forms in the ends of the long bones of the body, which include bones of the arms and legs. In children and adolescents, it often forms in the long bones, near the knee. Rarely, osteosarcoma may be found in soft tissue or organs in the chest or abdomen.

Signs and symptoms of osteosarcoma include swelling over a bone or a bony part of the body and joint pain.

These and other signs and symptoms may be caused by osteosarcoma or by other conditions. Check with a doctor if your child has any of the following:

  • Swelling over a bone or bony part of the body.
  • Pain in a bone or joint.
  • A bone that breaks for no known reason.

Source (and to learn more): National Cancer Institute

Other Sarcoma Projects Funded